In view of the forthcoming World day for Alzheimer on September 21st, the International Clinical Jérôme Lejeune Days (18th and 19th September) * are dedicating two conferences to :
- «Down Syndrome and dementia: the neurologist’s point of view» by IRA T. LOTT (neurologist, paediatrician at the university of California, Los Angeles).
- « Alzheimer’s disease in elderly subjects living with Down Syndrome: highlight on the various stages of development »– by WAYNE SILVERMAN (Head of research on genetic intelligence diseases at John Hopkins University, Baltimore).
Research PROJECTS on Alzheimer and Down Syndrome
Thanks to therapeutic progress, people with Down Syndrome live significantly longer. However, this increased life expectancy leads to the observation of pathologies related to ageing, amongst which Alzheimer’s disease.
Within this context and in order to understand the close connections there are between these two pathologies, The Jérôme Lejeune Foundation helps to develop the work of researchers concerning the connection there is between Down Syndrome and the acceleration of the brain ageing process and, particularly, Alzheimer’s disease. Thus, in 2014, it launched several calls for projects in order to understand the close connections there are between these two pathologies.
For its part, the Jérôme Lejeune Institute is currently finalizing a project of clinical research with its consultation service on the ageing of people with Down Syndrome and, particularly, concerning the link there is between Down Syndrome and Alzheimer’s disease.
Research on Alzheimer’s disease and research on Down Syndrome: A synergy for the benefit of many patients.
Research on Alzheimer’s disease and research on Down Syndrome: A synergy for the benefit of many patients. Scientists noticed that people with Down Syndrome could develop Alzheimer’s disease precociously. The “APP gene”, located on the chromosome 21, is at the origin of the amyloid plaques. An overexpression of this gene leads to an increase of the amyloid plaques, damage specific to Alzheimer.
The study of these mechanisms in patients with Down Syndrome can help research on Alzheimer’s disease to progress. Conversely, ageing people with Down Syndrome may benefit from research on Alzheimer. These are major perspectives for the health of all.
*The complete program of the International Clinical Jérôme Lejeune Days: www.jcijl.org
March 2014 : Interview on Alzheimer and Down Syndrome research by Valérie Legout ( Foundation’s international director for research) : “Research on Down Syndrome is at the service of society as a whole! »