Therapeutic Approaches

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Levels of Down syndrome Research

The therapeutic or clinical approach is the phase of research on humans, with a goal of objectivising treatment effectiveness.


  • The objective in treating Down syndrome is to improve the intellectual capacities of the patients.

  • Two complementary tracks are followed to better understand and treat those suffering from the disorder.

  • Optimising capacity by improving patient cerebral functioning through daily follow-up and adapted care. ACTHYF is a study conducted by the Jérôme Lejeune Institute to assess treatment benefits on the psychomotor development of young children and to optimise their learning capacity.

  • The second track is a research programme to better understand the mechanism of cellular malfunctions resulting from genetic defects. Better understanding them will allow development of treatments. CiBleS21 is this type of approach.


One of the current difficulties in research is developing proper assessment tools for persons with intellectual disabilities. Psychologists and other specialists, especially the Jérôme Lejeune Institute- the specialised medical office of the Jérôme Lejeune Foundation – are working on them.

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